GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9815354 | 1 | rs7372217 | chr3:41990122 | ULK4 | chr3:41288091-42003660:- | -0.51 | -6.12 | 7.79E-9 | Diastolic blood pressure |
| UCEC | cis | rs10935120 | 1 | rs7374158 | chr3:134270156 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs7374325 | chr3:134275601 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.63 | 7.74E-6 | Height |
| UCEC | cis | rs9894429 | 1 | rs7406003 | chr17:79597597 | TSPAN10 | chr17:79609349-79615778:+ | 0.62 | 7.56 | 3.56E-12 | Eye color traits |
| UCEC | cis | rs10935120 | 1 | rs7427492 | chr3:134261654 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.65 | 7.29E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs7428326 | chr3:134251184 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.62 | 8.08E-6 | Height |
| UCEC | cis | rs1432723 | 1 | rs74295103 | chr5:155319504 | PPP1R2P3 | chr5:156277549-156279539:+ | 0.43 | 5.02 | 1.44E-6 | Obesity-related traits |
| UCEC | cis | rs10935120 | 1 | rs7432268 | chr3:134242051 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.63 | 7.74E-6 | Height |
| UCEC | cis | rs10935120 | 1 | rs7433663 | chr3:134235790 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.63 | 7.91E-6 | Height |
| UCEC | cis | rs11782652 | 1 | rs74544416 | chr8:82657745 | CHMP4C | chr8:82644688-82671746:+ | -1.02 | -4.68 | 6.23E-6 | Epithelial ovarian cancer;Ovarian cancer |
| UCEC | cis | rs11782652 | 1 | rs74758321 | chr8:82667320 | CHMP4C | chr8:82644688-82671746:+ | -1.02 | -4.68 | 6.23E-6 | Epithelial ovarian cancer;Ovarian cancer |
| UCEC | cis | rs9894429 | 1 | rs7503679 | chr17:79583843 | TSPAN10 | chr17:79609349-79615778:+ | 0.66 | 8.57 | 1.11E-14 | Eye color traits |
| UCEC | cis | rs4660306 | 1 | rs7522705 | chr1:45992300 | CCDC163P | chr1:45960581-45965646:- | 0.5 | 6.76 | 2.81E-10 | Homocysteine levels |
| UCEC | cis | rs4660306 | 1 | rs7534467 | chr1:45988691 | CCDC163P | chr1:45960581-45965646:- | -0.57 | -7.31 | 1.45E-11 | Homocysteine levels |
| UCEC | cis | rs4660306 | 1 | rs7536557 | chr1:45992114 | CCDC163P | chr1:45960581-45965646:- | -0.47 | -6.31 | 2.91E-9 | Homocysteine levels |